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The oral dosage of aspirin that is needed to inhibit platelet aggregation is somewhat lower than the oral dosage needed to obtain analgesic and antipyretic effects, and it is much lower than the oral dosage needed to relieve inflammation caused by arthritic and other inflammatory disorders

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Without adequate glutathione to neutralize ROS, superoxide radicals collide with and damage the mitochondria's inner membrane (specifically a lipid called cardiolipin) and the mitochondrial DNA itself

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